Genetic polymorphisms associated with acute lung injury

Effect of Lung Recruitment Maneuver in Children with Acute Lung Injury

Background Acute lung injury (ALI) is defined as PaO2/FiO2 less than 300 with bilateral pulmonary infiltrates, without pressure is the top of the left atrium. Early diagnosis and treatment of pediatric ALI and find new cases is very important. Accurate diagnosis and effective steps to treating these patients is essential in the outcome of ALI. This study was conducted to show the impact of recr...

GADD45a Promoter Regulation by a Functional Genetic Variant Associated with Acute Lung Injury

RATIONALE Growth arrest DNA damage inducible alpha (GADD45a) is a stress-induced gene we have shown to participate in the pathophysiology of ventilator-induced lung injury (VILI) via regulation of mechanical stress-induced Akt ubiquitination and phosphorylation. The regulation of GADD45a expression by mechanical stress and its relationship with acute lung injury (ALI) susceptibility and severit...

Pancreatitis-associated acute lung injury: new insights.

Genetic Polymorphisms of CCL22 and CCR4 in Patients with Lung Cancer

Background: An association between lung cancer and chemokines has been advocated in the recent years. This study aims at investigating the association between lung cancer and 16C/A single nucleotide polymorphism (SNP) (rs. 4359426) in C-C motif chemokine 22 (CCL22) as well as C1014T SNP (rs. 2228428) in C-C chemokine receptor type 4 (CCR4), which serves as the receptor for CCL22.Methods: Genoty...

Patients With Acute Lung Injury*

natriuretic peptide (ANP) on hemodynamics, pulmonary gas exchange, and urine volume during mechanical ventilation with positive end-expiratory pressure (PEEP) in patients with acute lung injury. Design: Prospective, randomized, comparable study. Setting: ICU of a university hospital. Patients: Forty patients with moderate acute lung injury (lung injury score ^2.0) who required mechanical ventil...